• Zavos IUI Catheter
• Zavos Artificial Insemination (AI) Kit
• Insemination Device
• Makler Cannula
• Tom Cat IUI Catheter
• Makler Insemination Device

The Zavos IUI Catheter is a 5Fr. IUI catheter made out of clear polyethylene, 17cm in length. With an OD of 1.66mm and an ID of 0.65mm, a 5cm distal segment with double side eyes and a rounded tip insures a very smooth entry through the cervix with minimal disturbance to the endometrial stroma. This is accomplished with 11cm of marked catheter shaft with 7Fr. in diameter for superior and secure handling. A proximal Luer lock allows for proper connection with a syringe. The Zavos IUI catheter allows for the sperm to bypass the cervix so that an increased number of high quality sperm can reach the uterine cavity and the fallopian tubes.

Features

• Soft inner catheter with Double Side Eyes and Rounded Tip
• Super smooth entry to the endometrial stroma
• Outer shaft is marked in 1cm segments
• Standard Luer Lock
• Length: 17cm
• OD: 2.3mm Shaft (13cm length); 1.66mm Distal (5cm length)
• ID: 0.65mm

Indications for use of the Zavos IUI catheter

• Intrauterine insemination

• Not intended for IVF, GIFT or other intra fallopian tube procedures.
• Should not be used in the presence of cervical infection.
• Should not be used in the presence of or after recent pelvic inflammatory disease.

Warnings

• Always use washed spermatozoa when performing intrauterine artificial insemination, or intracervical artificial insemination.  The introduction of unwashed spermatozoa into the uterus will almost always result in severe adverse reactions, which may include anaphylactic shock.  Please refer to the SpermPrep^™ and  ZSC^™II methods shown in this catalog for  preparing spermatozoa for intrauterine insemination before performing this procedure.

Zavos Artificial Insemination (AI) Kit

The Zavos AI Kit offers the ultimate solution for the physician who wants to perform artificial inseminations in the office. This kit includes everything any physician would need to perform the in-office AI, including one vial for semen collection, one 5mL syringe, and one TomCat AI catheter. The Zavos Artificial Insemination Kits comes completely sterile and are packaged individually for your convenience.

Indications for use of the Zavos AI Kit

• Intrauterine insemination by Physician

• Not intended for IVF, GIFT or other intra fallopian tube procedures.
• Should not be used in the presence of cervical infection.
• Should not be used in the presence of or after recent pelvic inflammatory disease.

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Insemination Device

The Insemination Device includes one 5mL syringe and one TomCat AI catheter. The Insemination Device comes completely sterile and are packaged individually for your convenience.

Indications for use of the Zavos AI Kit

• Intrauterine insemination by Physician

• Not intended for IVF, GIFT or other intra fallopian tube procedures.
• Should not be used in the presence of cervical infection.
• Should not be used in the presence of or after recent pelvic inflammatory disease.

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Atraumatic: This disposable and sterilized cannula is semi-rigid with a rounded tip, and therefore atraumatic during the insemination procedure.

Optimal size: Suitable for uterine cavities of all sizes.  A small volume of washed and concentrated sperm is sufficient for insemination (0.5 ml.) an important fact in cases of oligospermic specimens.

Flexibility: Optimal rigidity enables the cannula to fit itself to the curvature of the uterus.

Cervix sealing:  The flared base shape, serves to seal the cervix to prevent the back-flow of the injected contents.
 
 

Suggestions for the preparation of the injected contents

Sperm preparation for IUI can be performed via the use of the SpermPrep^™ filtration method or the ZSC^™ methods. For further  information on how to better employ these methods in your lab or your practice please refer to those  products in this prospectus. Also, for further information,  if necessary, please call ZDL, Inc., or your local distributor.

For best results it is recommended to use this cannula together with The Makler Insemination Device.

The Makler Cannula (Catheter) is available also in a short size for intra-cervical insemination.

The Tom Cat IUI catheter is designed with a flexible body which enables the catheter to fit itself to the curvature of the uterus. It is relatively a small and maneuverable IUI catheter, 4.5" length, 3.5Fr. and open end. The Tom Cat IUI catheters are sterile, individually packaged and are sold in 50 catheters per box

Indications for use of the Tom Cat catheter

• Intrauterine insemination

Contraindications for use of the Tom Cat catheter

• Not intended for IVF, GIFT or other intra fallopian tube procedures.
• Should not be used in the presence of cervical infection.
• Should not be used in the presence of or after recent pelvic inflammatory disease.

• Always use washed spermatozoa when performing intrauterine artificial insemination, or intracervical artificial insemination.  The introduction of unwashed spermatozoa into the uterus will almost always result in severe adverse reactions, which may include anaphylactic shock.  Please refer to the SpermPrep^™ and  ZSC^™ methods shown in this catalog for  preparing spermatozoa for intrauterine insemination before performing this procedure.

• These catheters are not designed to be reused or resterilized.  Destroy after single use.

• No adverse reactions associated with the Tom Cat IUI Catheter have been reported.  However, as with any instrument which is passed through the internal cervical os, mild cramping may be expected.

Makler Insemination Device

The device is composed of two main parts: 

1. a semi-rigid atraumatic cannula that can be fitted to the tip of 1.0 ml tuberculin syringe.  There are two versions of this cannula: the long one is for intrauterine insemination and the short one is for intracervical deposition of spermatozoa.
2. A carrier to hold the syringe and to press the cannula against the outer cervix to prevent leakage of the injected contents.

About 0.2-0.5 ml of the contents prepared in a test tube is aspirated through the cannula into the syringe and the latter is inserted into the tip of the carrier.  Under direct speculum visualization the cannula is introduced into the cervical canal or uterine cavity according to type used.  Until the external os is entirely  obliterated  by the flared base of the cannula.  A tenaculum is not required unless the uterus is hyper flexed and pulling in order to straighten its angle is needed.  The clamp is fixed to the outer brim of the speculum and the tension of the spring is adjusted so that the cannula is gently pressed against the cervical outlet.  The contents are now slowly injected and the sealing mechanism prevents the backflow of the injected material.  The patient can be left in a supine position for 10-20 minutes before the set is removed.Suggestions for preparation of the injected contents

Raw seminal fluid should not be injected either to the uterine cavity or to the cervical canal, as this may irritate and induce cramps and fainting.  Only properly prepared sperm should be used and this can be achieved by using either the SpermPrep^™ filtration method or the ZSC^™ technology swim-up/swim-down technique (ZSC^™ and ZSC^™ II)with properly formulated SpermPrep^™ medium. Oligospermic specimens need to be centrifuged at 300 g for 10 minutes and the concentrated pellet be mixed and injected. 

Indications.

The use of this technique with the Makler Insemination Device is suggested in the following cases:

1. Infertility due to subfertile oligo-asthenospermic specimens.
2. Poor post coital tests due to cervical hostility, low semen volume or antisperm antibodies within cervical mucus.
3. To increase probability of fertilization in conjunction with induction of ovulation.
4. Cases of unexplained infertility.
5. To increase successful rate in donor insemination or to enable using one specimen for several different patients.